Irinotecan toxicity: genes or intestinal microflora?
نویسندگان
چکیده
منابع مشابه
Intestinal microflora and digestive toxicity of irinotecan in mice.
PURPOSE Delayed diarrhea is the most important side effect of irinotecan. The aim of this study was to investigate the role of intestinal microflora on the induction of systemic and intestinal toxicity and diarrhea, studying germ-free and holoxenic mice i.p. injected with irinotecan. EXPERIMENTAL DESIGN To evaluate the lethal dose, starting with 100 mg/kg/4 d, we treated the holoxenic mice wi...
متن کاملMetabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats.
One of the dose-limiting toxicities of irinotecan (CPT-11) is delayed-onset diarrhea, which is the greatest barrier to treatment with CPT-11-containing regimens. CPT-11 is converted to its active metabolite, SN-38, which is conjugated by hepatic uridine diphosphate glucuronosyl transferase to SN-38 glucuronide (SN-38G). SN-38G, once excreted in the intestinal lumen via bile, is extensively deco...
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Clinical observations, preclinical models, and pharmacokinetic studies have yielded some critical insights into the pathophysiology of these side effects. Early recognition and treatment of these toxicities have resulted in a reduction in patient morbidity. Despite these new pathophysiologic insights and advances in treatment, gastrointestinal toxicities remain a major problem with the clinical...
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Based on agglutination, complement fixation, bactericidal, and opsonization tests, it is evident that suspensions of a Bacteroides sp. isolated from the mouse intestine and given by parenteral routes do not initiate antibody formation in mice. Rats also respond poorly to the antigenic stimulus. In contrast, suspensions of other bacterial species isolated from the rodent intestine are highly imm...
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Large quantities of fluid administered through an intestinal tube caused alterations in small bowel bacteriology in four of seven subjects. In two normal individuals, colonic bacteria were found after fluid infusion in areas of the small bowel which previously had none. The faecal microflora was also altered by the fluid purge: anaerobes were reduced in some subjects and large numbers of Entero...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2009
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6604957